Cell Stress:
Survival and Apoptosis

Bari • 9-10 September 2016



  • Friday, 9 September

    12:00 Registration and welcome mingling cocktail
    14:00-14:10 Opening
    14:10-15:10 DNA and RNA stability
    Chair: Alessandra Montecucco (Pavia)
      Morena Catillo (Pavia)
    Splicing of transcripts for splicing factor SRSF1 is finely tuned in response to cell metabolism
      Cristina Mazzoni (Rome)
    RNA oxidation and ageing in mRNA degradation mutants of S. cerevisiae
      Annapina Russo (Naples)
    Regulatory role of rpL3 in cell response to nucleolar stress induced by Act D in tumor cells lacking functional p53
    15:10-16:10 Cell death and metabolism
    Chair: Valter Longo (Los Angeles, CA, USA)
      Nicoletta Guaragnella (Bari)
    Cell fate decision in yeast: within and between glucose sensing, Hog1 SAPK and mitochondrial retrograde pathways
      Enzo Martegani (Milan)
    Accumulation of activated Ras in mitochondria and apoptosis
      Flavia Cuviello (Potenza)
    Modulation of mitochondrial pyruvate carrier expression in HEK293 and HepG2 cells
    16:10-16:30 Coffee break and poster viewing
    16:30-17:30 Plenary Lecture
    Valter Longo (Los Angeles, CA, USA)
    Nutrient signaling, cellular protection and regeneration, and healthspan
    17:30-19:00 Poster Session
    19:00-20:00 Host-pathogen interaction
    Chair: Cristina Mazzoni (Rome)
      Rosanna Salvia (Potenza)
    The multifunctional polydnavirus ANK1 protein: new insights for apoptotis pathway
      Luisa Rubino (Bari)
    Carnation Italian ringspot virus p36 expression enhances necrotic cell death in response to acetic acid in Saccharomyces cerevisiae
      Gerarda Grossi (Potenza)
    The role of apoptosis in parasitism: the case of Aphidius ervi
    20:30 Social Dinner
  • Saturday, 10 September

    9:00-9:40 Cell stress and chaperones
    Chair: Enzo Martegani (Milan)
      Grazia Tamma (Bari)
    The abundance of the vasopressin regulated water channel AQP2 is controlled by the E3-ligase CHIP via HSP70, as possible anchoring protein for the E3-ligase MDM2
      Mark Woodford (Syracuse, NY, USA)
    The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding
    9:40-10:40 Environmental stress and anti-stress agents
    Chair: Francesca Zito (Palermo)
      Fiorenza Minervini (Bari)
    Influence of digestion process on antioxidant activity induced by artichoke and grape polyphenols in human intestinal model
      Viviana di Giacomo (Chieti)
    Oxidative stress, apoptosis and survival in human gingival fibroblasts exposed to e-cigarette fluids
      Mariarita Stirpe (Rome)
    Annurca apple (M. pumila Miller cv Annurca) extracts act against stress and ageing in S. cerevisiae yeast cells
    10:40-11:00 Coffee break
    11:00-12:00 Cell stress and disease
    Chair: Mark Woodford (Syracuse, NY, USA)
      Alessandra Stacchiotti (Brescia)
    Sirtuin 1 downregulation in obese mice: a multi-organ stress study
      Apollonia Tullo (Bari)
    TRIM8 role in the crosstalk between N-MYC-miR17 family pathway and p53 tumour suppressor protein in chemo-resistant tumours
      Manuela Loi (Bologna)
    Barrier-to-Autointegration Factor (BAF) evaluation during DNA-damage response
    12:10-12:40 Lecture in memory of Valeria Matranga
    Francesca Zito (Palermo)
    Valeria Matranga’s heritage: the sea urchin, a successful animal model
    12:40-13:00 Concluding remarks - Winner of the F. Ritossa award announced
    13:00 Cocktail with regional specialities
  • The poster's maximum size is 70 x 100 cm (width x height).

    Correct format... poster should be PORTRAIT  poster should NOT be LANDSCAPE Wrong format...


    P.1  Giovannella Bruscalupi (Rome)
    Sirtuin SRT2 mediates DNA damage response by modulating glutamate dehydrogenase activity in Arabidopsis thaliana

    P.2  Silvia Codenotti (Brescia)
    Erastin is a strong inducer of ferroptosis in human rhabdomyosarcoma cell lines 

    P.3  Agnieszka Felczykowska (Gdansk, Poland)
    Effect of usnic acid synthetic analogs on cancer cells

    P.4  Lucia Maita (Pavia)
    Chronic replication stress impacts on cell morphology and adhesion

    P.5  Daniela Pignataro (Pavia)
    DNA damage response induced by mitochondrial-driven oxidative stress in Parkinson’s disease cell model system

    P.6  Giulia Russo (Naples)
    rpL3 promotes the apoptosis of p53 mutated lung cancer cells by down-regulating CBS upon 5-FU treatment

    P.7  Roberta Russo (Palermo)
    Response of the AP-1 transcription factor to metals treatment, in P. lividus sea urchin embryos

    P.8  Sofia Scomazzon (Rome)
    Role of zinc-finger AN1-type domain-2a gene in human melanoma cell survival

    P.9  Giuseppe Sirago (Bari)
    Protection exerted by growth hormone secretagogues towards mitochondrial parameters analyzed in a rat model of cachexia

    P.10  Giulia Stamerra (Milan)
    DNA damage checkpoint deficiency and oxidative stress: implications for cell survival




Registrations & Abstracts:
7 July 2016

7 July 2016

Organising Committee

CNR Institute of Biomembrane and Bioenergetics (Bari)

CNR Institute of Molecular Genetics (Pavia)

With the support of





Valter Longo

Valter Longo, Ph.D.

Dr Longo is the Edna M. Jones Professor of Gerontology and Biological Sciences, and Director of the Longevity Institute at the University of Southern California-Davis School of Gerontology, Los Angeles. Dr. Longo's studies focus on the fundamental mechanisms of aging in simple organisms, mice and humans. The Longo laboratory has identified several genetic pathways that regulate aging in simple organisms and reduce the incidence of multiple diseases in mice and humans. His laboratory also described both dietary and genetic interventions that protect cells and improve the treatment and prevention of cancer and other diseases in mammals. Dr Longo's most recent studies are on dietary interventions that can affect stem cell-based regeneration to promote longevity in mice and humans. The Longevity Institute in Los Angeles, directed by Dr. Longo, includes over 40 faculty members focused on topics ranging from regeneration to dietary interventions aimed at improving health and lifespan in the near future. Among the accolades received by Dr. Longo are the 2010 Nathan Shock Lecture Award from the National Institute on Aging (NIA/NIH) and the 2013 Vincent Cristofalo “Rising Star” Award in Aging Research from the American Federation for Aging Research (AFAR).

Dr Longo was born and raised in Genoa, Italy and received his undergraduate degree from the University of North Texas, where he majored in biochemistry with a minor in jazz performance. He received his Ph.D. in Biochemistry from the University of California, Los Angeles (UCLA) in 1997 and his postdoctoral training in the Neurobiology of Aging and Alzheimer's Diseases at USC. He started his independent career in 2000 at the University of Southern California, School of Gerontology, one of the first and leading programs for aging research and education.